The Effect of the COVID- 19 Outbreak on Intensive Care in Northern Saitama, Japan

Background: The 2020 COVID- 19 pandemic had various effects on local healthcare. The aim of this study was to assess the extent to which local healthcare and healthcare workers were affected by the COVID- 19 pandemic. Method(s): In this observational study we examined and compared intensive care units (ICUs) before (2019) and during (2020) the COVID- 19 pandemic to assess its effects. Emergency patient data were obtained from the Saitama Prefecture Emergency Medical Information System. The effect of COVID- 19 on emergency care responses was compared with the admission and refusal of patients in 2019 and 2020. We also examined the number of patients who were admitted to ICUs and required surgery. The effect on ICUs was examined with the number of Nurses' incident reports and severity percentages calculated from the integrated team medical care and safety system. We also compared the overtime hours of physicians on the basis of employment records. Result(s): In 2019, 2,136 emergency requests were made to admit patients, and 1,811 patients (85%) were admitted. In contrast, in 2020, 2,371 emergency requests were made, and 1,822 patients (76%) were admitted, representing a decrease to 76% (p = 0.931). The percentage of patients for whom admission was refused was significantly greater in 2020 (506 patients, 21.3%) than in 2019 (303 patients, 14.1%;p = 0.0004). In 2020, the number of neurosurgical, cardiac, and vascular operations increased and, over time, the number of operations increased for all surgical units. The number of incidents reported in ICUs increased significantly from 396 in 2019 to 510 in 2020 (p = 0.001). Conclusion(s): Although intensive care management was restricted, the numbers of patients and physician overtime hours were greater during the COVID- 19 pandemic than before, and the resulting environment led to an increase in the number of incidents. The ICU environments must be proactively improved to prepare for more severe situations in the future.Copyright © 2022 Jikei University School of Medicine. All rights reserved.

Impact of the Covid-19 Pandemic on Pediatric Surgery at a Central Referral Hospital in Malawi

Introduction: The COVID-19 pandemic has disrupted health care systems worldwide, but the specific impact on pediatric surgery in low-and-middle-income countries has received little attention. This study evaluated the changes in pediatric surgical case volume at a central referral hospital in Malawi from 2019 through 2021 to quantify the impact of COVID-19. Method(s): We retrospectively reviewed all pediatric surgical cases performed at our institution from May-August 2019, 2020, and 2021. These months were chosen because they coincided with the first major wave of COVID cases in Malawi in 2020. We compared the number of cases performed per week between years and analyzed case numbers by specialty (general, orthopedic, plastic, neurosurgery, ENT, and urology). Result(s): A total of 1032 procedures were performed. There was a 32% reduction in case volume between 2019 to 2020 (344 to 235 cases, 19.5 vs 13.8 per week, p=0.04), with a subsequent 93% increase from 2020 to 2021 (235 to 435 cases, 13.8 vs 26.4 per week, p<0.001). The most significantly impacted specialties were ENT and plastics, both with 78% fewer procedures in 2020 compared with 2019, and a subsequent 4-fold and 22-fold increase in cases from 2020 to 2021, respectively (Chi-Square;p=0.007 and p<0.001). Orthopedic and Neurosurgical case numbers were impacted the least, with reductions ranging from 22% to 35%. Conclusion(s): The COVID-19 pandemic significantly reduced the number of pediatric surgical cases performed at the central referral hospital in Malawi across all specialties, thereby further limiting essential surgical services to an already marginalized patient population.

Surgical and nonsurgical interventions for Alzheimer's disease

Over the years, many surgical and nonsurgical interventions have been adapted to manage Alzheimer's disease (AD). While many of these tools were developed to primarily treat other neurological conditions, increased understanding of AD pathology has opened up new opportunities to apply established techniques in novel fashions. This chapter discusses neurosurgical interventions for AD especially in the context of the coronavirus pandemic. © 2023 Elsevier Inc. All rights reserved.

Supporting Future Generations of Neurosurgeons: Passing the Torch

In this chapter, Dr. Groff discusses how to support future neurosurgeons and guide them. Bond with your patients and form meaningful connections. Look for support within organized neurosurgery. Find balance in your family and meaningful avocations. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021.

Big data approach on the impact of COVID-19 lockdown on pediatric neurosurgery

Objective: COVID-19 lockdowns in 2020 limited activities of daily life. Data on the impact on healthcare systems is ambiguous. So far no data has been published for pediatric neurosurgery in Germany. We present the results of a big data approach. Method(s): We obtained anonymous data from the nationwide database of hospital statistics (German Federal Statistical Office, www. desta tis. de) in August 2022. For the age group <18 years in 2016- 2020, the following diagnoses (ICD-10 code) were analysed: Intracranial injury (S06), malignant (C71), benign (D33) and unspecified (D43) neoplasia, abuse (T74), violent attack (Y09) and, for comparison, forearm fracture (S52). The following operations (OPS code) were chosen: Operation of the central nervous system (CNS, 5-01- 05), excision of intracranial lesion (5-015), shunt insertion (5-023), shunt revision (5-024), plastic operations of the spinal cord (5-036) and, for comparison, overall number of operations (OPS-5), spondylodesis (5-836) and functional neurosurgery (5-028) at all ages. Result(s): The number of operations declined from 17.23 million in 2019 to 15.82 million in 2020 (8.2%). CNS operations declined by 5%. Shunt insertion declined by 8.1%, revision by 5.1% and spinal cord operations by 6.6%, whereas excisions of intracranial lesions increased by 1.7%. Spondylodesis and functional operations both decreased by 11.9%. The hospitalisations for intracranial neoplasia declined by 8.8% compared to previous years. The number of inpatients with intracranial injury declined by 16%. Violent attack was also documented less often (-13.2%), but child abuse increased by 3.3%. Forearm fractures declined by 5.6%. Conclusion(s): The COVID-19 lockdown in 2020 lead to reduction of operations. Neuro-oncological operations were not affected. Intracranial injury even declined by 16%, reflecting limited activities and mobility. An increase in documented child abuse by 3.3% compared to the average of previous years was observed. These results help understand the impact of pandemics and political decisions and guide future decision-making.

Telemedicine Utilization in an Outpatient Pediatric Neurosurgical Clinic: A Prospective Survey of Patient and Family Preferences.

OBJECTIVE: After becoming widespread during the COVID-19 pandemic, telemedicine continues to play an important role in outpatient neurosurgical care. Nevertheless, the factors that influence individual decisions to choose telemedicine versus in-person appointments remain understudied. Here, we performed a prospective survey of pediatric neurosurgical patients and caregivers presenting for telemedicine or in-person outpatient visits, to identify factors associated with appointment choice. METHODS: All patients and caregivers with an outpatient pediatric neurosurgical encounter at Connecticut Children's between January 31st and May 20th, 2022, were invited to participate in this survey. Data related to demographics, socioeconomics, technological access, COVID-19 vaccination status, and appointment preferences were collected. RESULTS: During the study period, there were 858 unique pediatric neurosurgical outpatient encounters (86.1% in-person and 13.9% telemedicine). A total of 212 (24.7%) respondents completed the survey. Those with a telemedicine appointment were more likely to be white (P = 0.005), not Hispanic or Latino (P = 0.020), have private insurance (P = 0.003), be established patients (P < 0.001), have a household income >$80,000 (P = 0.005), and have caregivers who completed a 4-year college degree (P < 0.001). Those who were seen in-person cited the patient's condition, quality of care, and communication as important factors, whereas those who were seen via telemedicine cited time, travel, and convenience. CONCLUSIONS: While convenience influences some to choose telemedicine, concerns regarding the quality of care persist among those who prefer in-person encounters. Recognizing these factors will minimize barriers to care, better define the appropriate populations/contexts for each encounter type, and improve the integration of telemedicine within an outpatient neurosurgical setting.

A Thorn in his Side

History: A 20 year old D1 men's basketball player with a history of COVID the month prior presented with worsening low back pain. He denied any injury, but reported the pain started as low back discomfort after a basketball game the week prior. He noted a progression and radiation of pain down his right lower extremity to his toes. He had tried physical therapy and dry needling, as well as cyclobenzaprine and naproxen from team physicians with mild improvement. The pain worsened and he went to the ED for evaluation. He was afebrile and had a lumbar radiograph with no acute fracture, grade 1 anterolisthesis of L5 on S1. He was discharged home with norco. Over the next 2 days, he developed chills and in the context of his worsening back pain, his team physicians ordered an MRI. Physical Exam: BMI 26.9 Temp 97.9degree Heart rate: 73 Respiratory rate 14 BP: 124/64 MSK: Spine- Intact skin with generalized pain over lumbar area, worse over the right paraspinal musculature. 5/5 strength of bilateral lower extremity flexion and extension of his hips, knees, and plantar and dorsiflexion of ankles and toes. Bilateral intact sensibility in the sciatic, femoral, superficial, and deep peroneal, sural, and saphenous nerve distributions. Slightly diminished sensibility over the right deep peroneal nerve distribution compared to left. 2/4 patellar and achilles DTRs. No clonus, downgoing Babinski sign. Positive straight leg raise at 45 degrees with the right lower extremity. Differential Diagnosis: 141. Sciatica 142. Lumbar Muscle Strain 143. Disk Herniation 144. Spondylolisthesis 145. Vertebral Osteomyelitis Test Results: CBC:WBC10, HGB13.2, neutrophils 75.7% (red 45%-74%). Unremarkable CMP. CRP =7.31, ESR 23 Blood culture negative, throat culture negative. TB test negative. COVID test negative. Flu test negative. Urine culture and UDS negative. HIV test negative. Procalcitonin of 0.07. IR guided aspiration and bacterial Culture yielded MSSA. MRI w/contrast: showing L1-L4 facet edema concerning for infectious spondylitis, intramuscular, and epidural abscess. Final Diagnosis: Acute intramuscular abscess, vertebral osteomyelitis, with epidural abscess. Discussion(s): Vertebral osteomyelitis is a serious but quite rare disease in the immunocompetent, elite athlete population. Staphylococcus Aureus is the culprit a majority of the time, with only 50% of cases showing neurologic symptoms. This case was unique given the proximity to a dry needling treatment which is the only explainable vector of infection, normal blood cultures in this disease which hematogenously spreads, negativeHIV and other infectious disease testing, and otherwise benign history. Early recognition of this disease yields better outcomes and reduces incidence of severe debility. 5% to 10%of patients experience recurrence of back pain or osteomyelitis later on in life. Outcome(s): Patient was hospitalized and started on Cefepime and Vancomycin. Had an echocardiogram revealing changes consistent with athlete's heart without signs of vegetation on his cardiac valves. Neurosurgery declined to treat surgically. He continued to improve until he was ultimately discharged on hospital day 4 with a picc line and Nafcillin and was later changed to oral augmentin per ID. Follow-Up: By his 6 week follow-up visit with infectious disease and the team physicians, his back pain had completely resolved and was cleared to start a return to play protocol. There was no progression of disease since starting antibiotics, and no recurrence of back pain since treatment.

Neurosurgical care for patients with high-grade gliomas during the coronavirus disease 2019 pandemic: Analysis of routine billing data of a German nationwide hospital network

Background Little is known about delivery of neurosurgical care, complication rate and outcome of patients with high-grade glioma (HGG) during the coronavirus disease 2019 (Covid-19) pandemic. Methods This observational, retrospective cohort study analyzed routine administrative data of all patients admitted for neurosurgical treatment of an HGG within the Helios Hospital network in Germany. Data of the Covid-19 pandemic (March 1, 2020-May 31, 2022) were compared to the pre-pandemic period (January 1, 2016-February 29, 2020). Frequency of treatment and outcome (in-hospital mortality, length of hospital stay [LOHS], time in intensive care unit [TICU] and ventilation outside the operating room [OR]) were separately analyzed for patients with microsurgical resection (MR) or stereotactic biopsy (STBx). Results A total of 1763 patients underwent MR of an HGG (648 patients during the Covid-19 pandemic;1115 patients in the pre-pandemic period). 513 patients underwent STBx (182 [pandemic];331 patients [pre-pandemic]). No significant differences were found for treatment frequency (MR: 2.95 patients/week [Covid-19 pandemic] vs. 3.04 patients/week [pre-pandemic], IRR 0.98, 95% CI: 0.89-1.07;STBx (1.82 [Covid-19 pandemic] vs. 1.86 [pre-pandemic], IRR 0.96, 95% CI: 0.80-1.16, P > .05). Rates of in-hospital mortality, infection, postoperative hemorrhage, cerebral ischemia and ventilation outside the OR were similar in both periods. Overall LOHS was significantly shorter for patients with MR and STBx during the Covid-19 pandemic. Conclusions The Covid-19 pandemic did not affect the frequency of neurosurgical treatment of patients with an HGG based on data of a large nationwide hospital network in Germany. LOHS was significantly shorter but quality of neurosurgical care and outcome was not altered during the Covid-19 pandemic.

Improving Access to Extracranial-Intracranial Bypass Surgery in Border Hispanic Communities Utilizing Collaborative Approach Between Plastics and Neurological Surgery

INTRODUCTION: Hispanic patients such as those with Moyamoya disease are less likely to receive surgical revascularization therapy due to inequities in access (1). Our institution is a located in the Southern Texas- Mexico border region serving a largely Hispanic population. We previously referred patients for EC-IC bypass to other quaternary-care centers in Texas. While referrals were already challenging due to distance, mixed immigration status, and poor socioeconomic background of many patients;COVID-19 further exacerbated this problem with restriction of elective surgical volume. METHOD(S): A consecutive series of EC-IC bypasses performed by authors (SKD and MDLG) were retrospectively reviewed. Baseline clinical, perioperative radiographic, and post-operative outcomes were studied. All patients were offered option of a referral to a quaternary-care centers and also given local option for performing bypass surgery. Further, patients met preoperatively with both the plastic and neurological surgeon. Ultimately, decision was made by patient. RESULT(S): A total of 6 craniotomies for EC-IC bypass were performed during the study period. The diagnoses included Moyamoya in 5 cases and symptomatic intracranial atherosclerosis in one. All patients were Hispanic, female, and nonsmokers with mean age of 35.6 years. Mean preoperative HBa1c was 7.9, preoperative LDL was 82, and mean preoperative hemoglobin was 11.3. Direct bypass was performed in 40% of cases. Mean OR time was 3 hours and 7 minutes. CONCLUSION(S): We have found collaboration between plastic and neurological surgery for surgical revascularization is feasible and improved access to care for Hispanic Moyamoya disease patients residing in a border community.

Hybrid learning in neurosurgery

Hybrid learning substitutes the process of in-person, face-to-face knowledge transfer with online learning. By exploiting connectivism in the digital era through the internet and social media platforms, novel learning frameworks can and have been designed. Implementation of hybrid learning models is a timely move that has its niche embedded at the intersection of the twentieth century's digital age and the twenty-first century's age of knowledge. The application of hybrid learning in the surgical spheres, which demand duality of excellence in theory and practice, is relatively novel. It is easier to conceptualize online theoretical knowledge exchanges than it is to imagine hybrid learning as a strategy contributing to the neurosurgical practice of apprenticeship. The digital era follows the specialty of neurosurgery by almost half a century. Nevertheless, the indelible mark that computerization left on the twentieth century supports it as a feasible platform for paving the way for the age of knowledge. Harnessing digitization is increasingly important in a world riddled with uncertainty as exemplified by the COVID-19 pandemic. In addition, the globalization of neurosurgery becomes seamless when the integration of social media and virtual conferencing unite diverse groups. Qualitative feedback on early hybrid pedagogical frameworks have reported high acceptance rates and an appreciation for the innovative trends contrasting traditional learning. Pedagogy in this chapter refers to the practice of learning. This chapter delves into the definitions, learning theories, and clinical applications of hybrid learning in neurosurgery, namely diagnostics, surgical planning, skill apprenticeship, research, and global neurosurgery. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022. All rights reserved.

The Role of Neurosurgery in Worldwide Health Care and Its Disparities: An Overview

Neurosurgery is a relatively new branch of surgery that is increasingly important in global health. Neurosurgery has benefited from many recent technological improvements that have significantly increased the number of common conditions that can be effectively treated. Unfortunately, access to neurosurgeons is disproportionately concentrated in high-income countries, while many low- and middle-income countries have a drastic lack of neurosurgical workforce. This leads to extreme health disparities in the absence of urgently needed neurosurgical procedures. Access to current information can be improved by including LMICs in randomized clinical trials (RCTs) and by using the consensus conference method approach when RCT-derived evidence-based clinical guidelines are not applicable to LMICs. HICs must also contribute to meet the equipment needs of LMICs as well as share knowledge on how low-cost devices may be appropriately used in resource-constrained clinical environments. Finally, efforts to reduce disparities can benefit from the many new, more inclusive methods of communication we have learned to use effectively during the global SARS-CoV-2 pandemic. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Harnessing technology, a step forward to become "der herr der welt" of neurosurgery

While neurosurgical advancement, both in operative and educational domains, have been rapid in the past few years, most of them were made by the countries who already have well established systems. A huge part of the world lacks such opportunities, and paradoxically they are most in need as they do not have enough learning opportunities, well-trained personnel, and available mentors for training purpose. Additionally, local field competitions leading to turf war, internal politics, red tape, and complex-ossified bureaucratic procedures also hinder the progress towards the technological advancement in these countries. The recent emergence of Covid-19 Global crisis with new recommendations for in-person activities and limitation of movement and educational activities has necessitated the implementation and development of unique tools to keep both the surgeries and education going as normally as during the pre-pandemic time. The word latest advances in management strategies and teaching methodology generally means acquisition of some new novel technology and surgical techniques. Most of them are in experimental phases and still evolving. In reality, this is a much deeper term to understand. It must include a thorough understanding of all the available techniques and application of the best ones in one's armamentarium that should lead to the best results while it is cost-effective and feasible for one's given circumstances. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022. All rights reserved.

The Impact of the COVID-19 Pandemic on Neurosurgery Worldwide

The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2), first appeared in December 2019 and was declared a pandemic by the World Health Organization on March 11, 2020 (World Health Organization. WHO director-general's opening remarks at the media briefing on COVID-19—11 March 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19%2D%2D-11-march-2020. Accessed 2020). By September 9, 2020, 27.7 million cases and 0.9 million deaths were confirmed globally (Center for Systems Science and Engineering – Johns Hopkins Coronavirus Resource Center: COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. https://coronavirus.jhu.edu/map.html. Accessed 2020). This disease placed an unprecedented strain on healthcare systems around the world (Remuzzi and Remuzzi. Lancet. 395(10231):1225–8, 2020) and had a substantial effect on clinical practice across all surgical specialties, with neurosurgery being no exception (Bernstein. J Neurosurg. 2020:1–2. https://doi.org/10.3171/2020.4.JNS201031). Many hospitals implemented no-visitor policies and COVID-19 testing for all inpatients in order to prevent spread and protect patients and healthcare workers (Calderwood. Infect Control Hosp Epidemiol. 2020:1–9. https://doi.org/10.1017/ice.2020.303). To conserve beds, workforce, and valuable resources such as masks, gowns, and ventilators, surgeons had to restrict operations to emergency and essential interventions. Some neurosurgeons were redeployed to new intradepartmental roles, others lateralized to provide care for coronavirus patients. In order to limit in-person interactions and contagion, there was a surge in telehealth and digital innovation for remote monitoring and management. Research laboratories were closed for prolonged periods. Medical education and residency training were also substantially altered, with cancellation of many in-person events and a transformation to online meetings and educational sessions. In this chapter, we discuss the impact of COVID-19 on the global neurosurgery community with respect to clinical care, education, and research. While the pandemic has caused tremendous disruption in global neurosurgery already, there is hope that many of the lessons learned during this time have contributed to our resilience and preparedness for the future, be it a second wave of COVID-19 or a new unexpected challenge. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

Distance learning and on job training from a messenger pigeon to implanted brain microchips interface and metaverse

Transportation and transferring data and information around the globe have remarkably developed and revolutionized! It is possible to transfer data and information in a small part of a second (milliseconds) or in a real time. This technology is not only written texts but expanded to include visual material, virtual reality, visual and sound interactions. Such a great development definitely has and will continue to have an impact on shaping the methods of distance learning. Distance learning is no longer luxury, it becomes the heart of the education process and career development. There are several needs and objectives for distance learning to flourish the distance learning, education, and training in the near future. The COVID-19 pandemic demonstrated the need to develop professional, efficient safe, secure, and reliable methods of distance education, learning, and telemedicine. These emerged technologies of communication and transferring information provoked several serious ethical considerations The developing and advancing distance learning and on job training and professional assessment should be based on ethics and values (Values-Based Medical Education). Telemedicine and telesurgery which have great advantages and benefits are facing serious ethical and practical challenges too, which is going to be discussed in this chapter. The great future challenges are not the materials to be transferred but the methods of transferring these materials. The ways of transferring information are greatly varied from internet, computer-based programs, mobile application, and possibly by stimulating certain neural cells through implanted microchips. The emerging metaverse as a virtual augmented reality which is going to create unlimited applications may advance the distance education and on job training beyond any imagination. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022. All rights reserved.

An assessment of the long-term impacts of the coronavirus disease 2019 pandemic on academic neurosurgery.

OBJECTIVE: The goal of this study was to survey residents, fellows, and residency program leadership to assess the long-term impacts of the coronavirus disease 2019 (COVID-19) on residency training by using a structured survey methodology. METHODS: A survey was distributed to US neurosurgical residents and fellows (n = 2085) as well as program directors (PDs) and chairs (n = 216) in early 2022. Bivariate analysis was performed to identify factors associated with a decreased likelihood of pursuing a career in academic neurosurgery because of the pandemic, a perception that surgical skills preparation was negatively impacted, personal financial concerns, and a preference for remote education. Significant differences in the bivariate analysis underwent further multivariate logistic regression analysis to evaluate for predictors of these outcomes. RESULTS: An analysis of complete surveys from 264 residents and fellows (12.7%) and 38 PDs and chairs (17.6%) was performed. Over half of the residents and fellows (50.8%) believed that their surgical skills preparation was negatively impacted by the pandemic, and a notable proportion believed that they were less likely to go into academics because of the pandemic's impact on their professional (20.8%) and personal (28.8%) life. Those less likely to pursue academics were more likely to report that work-life balance did not improve (p = 0.049), personal financial concerns increased (p = 0.01), and comradery among residents (p = 0.002) and with faculty (p = 0.001) did not improve. Residents who indicated they were less likely to go into academics were also more likely to have been redeployed (p = 0.038). A large majority of PDs and chairs indicated that the pandemic resulted in financial setbacks for their departments (71.1%) and institutions (84.2%), with 52.6% reporting reduced faculty compensation. Financial setbacks at the institutional level were associated with a worsened opinion of hospital leadership (p = 0.019) and reports of a reduced quality of care for non-COVID-19 patients (p = 0.005) but not from faculty member losses (p = 0.515). A plurality of trainees (45.5%) reported a preference for a remote format for educational conferences compared to 37.1% who disagreed. CONCLUSIONS: This study provides a cross-section of the pandemic's impact on academic neurosurgery, highlighting the importance of continued efforts to assess and address the long-term consequences of the COVID-19 pandemic for US academic neurosurgery.

Multifocal glioblastoma and hormone replacement therapy in a transgender female.

Background: Glioblastoma multiforme represents approximately 60% of all brain tumors in adults. This malignancy shows a high level of biological and genetic heterogeneity associated with exceptional aggressiveness, leading to poor patient survival. One of the less common presentations is the appearance of primary multifocal lesions, which are linked with a worse prognosis. Among the multiple triggering factors in glioma progression, the administration of sex steroids and their analogs has been studied, but their role remains unclear to date. Case Description: A 43-year-old transgender woman who has a personal pathological history of receiving intramuscular (IM) hormone treatment for 27 years based on algestone/estradiol 150 mg/10 mg/mL. Three months ago, the patient suddenly experienced hemiplegia and hemiparesis in her right lower extremity, followed by a myoclonic focal epileptic seizure, vertigo, and a right frontal headache with a visual analog scale of 10/10. Magnetic resonance imaging images revealed an intra-axial mass with poorly defined, heterogeneous borders, and thick borders with perilesional edema in the left parietal lobe, as well as a rounded hypodense image with well-defined walls in the right internal capsule. The tumor was resected, and samples were sent to the pathology department, which confirmed the diagnosis of wild-type glioblastoma. Conclusion: This report identifies prolonged use of steroid-based hormone replacement therapy as the only predisposing factor in the oncogenesis of multifocal glioblastoma. It is an example that highlights the importance for physicians not to consider pathologies related to the human immunodeficiency virus rather than neoplasms in transgender patients in view of progressive neurological deterioration.

COVID-19 impact on the global neurosurgery resident training course and admission: A scoping review.

Background: This study looks at how COVID-19 affected the admission and training of neurosurgical residents worldwide. Methods: From 2019 to 2021, we reviewed multiple databases (i.e., Google Scholar, Science Direct, PubMed, and Hinari) to evaluate the impact of the COVID-19 pandemic on neurosurgery resident training and admission in low middle-income countries (LMICs) and high-income countries (HICs). We then utilized a Wilcoxon signed-rank test to evaluate the difference between the two LMIC/HICs and employed Levene's test to assess the homogeneity of variances. Results: There were 58 studies that met our inclusion criteria; 48 (72.4%) were conducted in HIC and 16 (27.6%) in LMIC. The admission of new residents was mostly canceled in HIC (31.7%; n = 13) and in LMIC (25%; n = 4) from 2019 to 2021 due to COVID-19. Learning modalities changed to include predominantly video conferencing (i.e., 94.7% [n = 54] of cases). Further, neurosurgery was largely restricted to emergency cases alone (79.6% [n = 39]), with only 12.2% (n = 6) elective cases. The result was a marked reduction in resident surgical training (i.e., 66.7% [n = 10] in LMIC and 62.9% [n = 22] in HIC), despite increased workloads in (i.e., LMIC [37.4%; n = 6] and HIC [35.7%; n = 15]). This was attributed to the marked reduction in the number of surgical patients allotted to each resident (i.e., LMIC [87.5%; n = 14] than HIC [83.3%; n = 35]). Conclusion: The COVID-19 pandemic markedly disrupted neurosurgical education globally. Although differences have been found between LMICs and HICs training, the reduction of neurosurgical case-loads and surgical procedures has significantly impacted neurosurgical training. The question remains, how can this "loss of experience" be redressed in the future?

Variation in postoperative outcomes of patients with intracranial tumors: insights from a prospective international cohort study during the COVID-19 pandemic.

BACKGROUND: This study assessed the international variation in surgical neuro-oncology practice and 30-day outcomes of patients who had surgery for an intracranial tumor during the COVID-19 pandemic. METHODS: We prospectively included adults aged ≥18 years who underwent surgery for a malignant or benign intracranial tumor across 55 international hospitals from 26 countries. Each participating hospital recorded cases for 3 consecutive months from the start of the pandemic. We categorized patients' location by World Bank income groups (high [HIC], upper-middle [UMIC], and low- and lower-middle [LLMIC]). Main outcomes were a change from routine management, SARS-CoV-2 infection, and 30-day mortality. We used a Bayesian multilevel logistic regression stratified by hospitals and adjusted for key confounders to estimate the association between income groups and mortality. RESULTS: Among 1016 patients, the number of patients in each income group was 765 (75.3%) in HIC, 142 (14.0%) in UMIC, and 109 (10.7%) in LLMIC. The management of 200 (19.8%) patients changed from usual care, most commonly delayed surgery. Within 30 days after surgery, 14 (1.4%) patients had a COVID-19 diagnosis and 39 (3.8%) patients died. In the multivariable model, LLMIC was associated with increased mortality (odds ratio 2.83, 95% credible interval 1.37-5.74) compared to HIC. CONCLUSIONS: The first wave of the pandemic had a significant impact on surgical decision-making. While the incidence of SARS-CoV-2 infection within 30 days after surgery was low, there was a disparity in mortality between countries and this warrants further examination to identify any modifiable factors.

Smart Healthcare Applications over 5G Networks: A Systematic Review

Provisioning of health services such as care, monitoring, and remote surgery is being improved thanks to fifth-generation cellular technology (5G). As 5G expands globally, more smart healthcare applications have been developed due to its extensive eMBB (Enhanced Mobile Broadband) and URLLC (Ultra-Reliable Low Latency Communications) features that can be used to generate healthcare systems that allow minimizing the face-to-face assistance of patients at hospital centers. This powerful network provides high transmission speeds, ultra-low latency, and a network capacity greater than that of 4G. Fifth-generation cellular technology is expected to be a means to provide excellent quality of medical care, through its technological provision to the use of IoMT (Internet of Medical Things) devices. Due to the numerous contributions in research on this topic, it is necessary to develop a review that provides an orderly perspective on research trends and niches for researchers to use as a starting point for their work. In this context, this article presents a systematic review based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), with article selection based on inclusion and exclusion criteria that avoid bias. This research was based on research questions that were answered from the included works. These questions focus on technical characteristics, health benefits, and security protocols necessary for the development of smart healthcare applications. We have identified that a high percentage of existing works in the literature are proposals (56.81%, n = 25) and theoretical studies (22.73%, n = 10);few implementations (15.91%, n = 7) and prototypes (4.55%, n = 2) exist, due to the limited global deployment of 5G. However, the panorama looks promising based on proposals and future work that these technological systems allow, all based on improving healthcare for people.